Non-Enzymatic Glycation of Transferrin and Diabetes Mellitus
نویسندگان
چکیده
منابع مشابه
Non-enzymatic glycation in diabetic complications.
D mellitus (DM) is associated with a greatly increased risk of secondary complications, such as cutaneous manifestations, myocardial infarction, nephropathy, retinopathy, and polyneuropathy. The non-enzymatic glycation of proteins followed by the formation of advanced glycation end products (AGEs) plays an important role in the pathology of diabetic complications.1 Occasionally endocrinological...
متن کاملNon-enzymatic glycation of proteins: a cause for complications in diabetes.
Diabetes mellitus is one of the most common non-communicable diseases, and is the fifth leading cause of death in most of the developed countries. It can affect nearly every organ and system in the body and may result in blindness, end stage renal disease, lower extremity amputation and increase risk of stroke, ischaemic heart diseases and peripheral vascular disease. Hyperglycemia in diabetes ...
متن کاملStudy of Nonenzymatic Glycation of Transferrin and its Effect on Iron -Binding Antioxidant Capacity
Objective(s) Nonenzymatic glycosylation (glycation) occurs in many macromolecules in aging and diabetes due to exposure of biomolecules to high level of glucose. Glycation can changes function, activities and structure of many biomolecules. Considering this important role of transferrin (Trf) in iron transport and antioxidant activity in plasma this study was carried out to investigate the eff...
متن کامل[Oxidative stress and protein glycation in diabetes mellitus].
Metabolic alterations of diabetes mellitus are not only informative biological signs, but also factors of degenerative complications. Thus, hyperglycaemia increases non enzymatic glycation, characterized by the binding of simple oses (glucose) or by-products to amino groups of proteins. This reaction leads to the formation of complex compounds, advanced glycation end products (AGEs), which alte...
متن کاملEffects of non-enzymatic glycation on cancellous bone fragility.
Post-translational modifications of collagen, such as non-enzymatic glycation (NEG), occur through the presence of extracellular sugars and cause the formation of advanced glycation end-products (AGEs). While AGEs have been shown to accumulate in a variety of collagenous human tissues and alter the tissues' functional behavior, the role of AGEs in modifying the mechanical properties of cancello...
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ژورنال
عنوان ژورنال: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy
سال: 2021
ISSN: 1178-7007
DOI: 10.2147/dmso.s304796